PHARMAXIN-200
antibiotic injectable solution
tylosin tartrate – 20%
tylosin tartrate – 20%
PHARMAXIN-200
antibiotic injectable solution
10 ml |
50 ml |
100 ml |
Composition
1 ml of the drug contains the active substance tylosin tartrate 220 mg in terms of tylosin base 200 mg.
Excipients: benzyl alcohol, propylene glycol, sodium citrate, water for injections.
Pharmacologicalproperties
Tylosin tartrate is a macrolide antibiotic, active against Gram-positive and Gram-negative bacteria including Staphylococcus spp., Streptococcus spp., Diplococcus spp., Corynebac- terium spp., Clostridium spp., Erysipelothrix rhusiopathiae, Neisserias spp., Bacteroides no- dosus, Moraxella bovis, Pasteurella spp., Spirochаetes. Mycoplasmas are particularly susceptible to Tylosin (Mycoplasma gallisepticum, Mycoplasma hyopneumoniae, My- coplasma synoviae, Mycoplasma meleagridis, Mycoplasma agalactiae, Mycoplasma bovi- genitalium), as well as Chlamydia and Rickettsia.
The mechanism of the medicinal product action is the blocking of protein synthesis in the bacterial cell by forming a complex with 50S ribosomal subunits.
Administration
Cattle: treatment of animals suffering from necrotizing pododermatitis (caused by Fusobacterium necrophorum), metritis (caused by Arcanobacterium pyogenes), and respiratory diseases (caused by Pasteurella multocida and Arcanobacterium pyogenes) sensitive to tylosin.
Sheep, goats: treatment of animals with bronchopneumonia (caused by Pasteurella spp. and Bordetella bronchiseptica), metritis (caused by Arcanobacterium pyogenes)), sensitive to tylosin.
Pigs: treatment of animals suffering from enzootic bronchopneumonia (caused by Pasteurella spp.), distemper (caused by Erysipelothrix rhusiopathiae), dysentery (caused by Treponema hyodysenteriae), arthritis (caused by Mycoplasma synoviae), sensitive to tylosin.
Routesof administration and dosages
Intraulcerally once a day for 3-5 days in doses:
cattle - 0.2-0.5 ml of the drug per 10 kg of body weight, which is equivalent to
4-10 mg of tylosin per 1 kg of body weight;
sheep, goats - 0.5 ml of the drug per 10 kg of body weight, which is equivalent to 10 mg of tylosin per
1 kg of body weight;
pigs - 0.1-0.5 ml of the drug per 10 kg of body weight, which is equivalent to 2-10 mg of tylosin per 1 kg of body weight.
Withdrawalperiod
Animals can be slaughtered for meat after 28 days (cattle), 16 days (pigs) and 42 days (sheep, goats) after the last administration of the drug. Milk consumption is allowed 5 days (cattle), 4 days (sheep, goats) after the last use of the drug. The meat and milk obtained by the specified deadline are disposed of or fed to unproductive animals, depending on the opinion of the veterinary medicine doctor.
Self life
24 months. After first opening – 14 days at +5 to +25° С.
Storageconditions
Store in dry, dark places, out of the reach of children, at +5 to +25° С.
1 ml of the drug contains the active substance tylosin tartrate 220 mg in terms of tylosin base 200 mg.
Excipients: benzyl alcohol, propylene glycol, sodium citrate, water for injections.
Pharmacologicalproperties
Tylosin tartrate is a macrolide antibiotic, active against Gram-positive and Gram-negative bacteria including Staphylococcus spp., Streptococcus spp., Diplococcus spp., Corynebac- terium spp., Clostridium spp., Erysipelothrix rhusiopathiae, Neisserias spp., Bacteroides no- dosus, Moraxella bovis, Pasteurella spp., Spirochаetes. Mycoplasmas are particularly susceptible to Tylosin (Mycoplasma gallisepticum, Mycoplasma hyopneumoniae, My- coplasma synoviae, Mycoplasma meleagridis, Mycoplasma agalactiae, Mycoplasma bovi- genitalium), as well as Chlamydia and Rickettsia.
The mechanism of the medicinal product action is the blocking of protein synthesis in the bacterial cell by forming a complex with 50S ribosomal subunits.
Administration
Cattle: treatment of animals suffering from necrotizing pododermatitis (caused by Fusobacterium necrophorum), metritis (caused by Arcanobacterium pyogenes), and respiratory diseases (caused by Pasteurella multocida and Arcanobacterium pyogenes) sensitive to tylosin.
Sheep, goats: treatment of animals with bronchopneumonia (caused by Pasteurella spp. and Bordetella bronchiseptica), metritis (caused by Arcanobacterium pyogenes)), sensitive to tylosin.
Pigs: treatment of animals suffering from enzootic bronchopneumonia (caused by Pasteurella spp.), distemper (caused by Erysipelothrix rhusiopathiae), dysentery (caused by Treponema hyodysenteriae), arthritis (caused by Mycoplasma synoviae), sensitive to tylosin.
Routesof administration and dosages
Intraulcerally once a day for 3-5 days in doses:
cattle - 0.2-0.5 ml of the drug per 10 kg of body weight, which is equivalent to
4-10 mg of tylosin per 1 kg of body weight;
sheep, goats - 0.5 ml of the drug per 10 kg of body weight, which is equivalent to 10 mg of tylosin per
1 kg of body weight;
pigs - 0.1-0.5 ml of the drug per 10 kg of body weight, which is equivalent to 2-10 mg of tylosin per 1 kg of body weight.
Withdrawalperiod
Animals can be slaughtered for meat after 28 days (cattle), 16 days (pigs) and 42 days (sheep, goats) after the last administration of the drug. Milk consumption is allowed 5 days (cattle), 4 days (sheep, goats) after the last use of the drug. The meat and milk obtained by the specified deadline are disposed of or fed to unproductive animals, depending on the opinion of the veterinary medicine doctor.
Self life
24 months. After first opening – 14 days at +5 to +25° С.
Storageconditions
Store in dry, dark places, out of the reach of children, at +5 to +25° С.