Composition
One dose of the vaccine (2.0 ml) contains:
Active ingredients:
Cattle rotavirus, strain RP-182 ≥ 7,0 lg TCID50;
Cattle coronavirus, strain CV-315 ≥ 256 HAU;
Escherichia coli, strain EC18 ≥ 9.0 lg CFU;
Clostridium perfringens type С, strain Cl.p.-19, toxoid ≥ 20.0 IU
Excipients: adjuvant Aerosil A-300 – 10 mg.
Pharmaceutical form
Suspension.
Immunobiological properties
The vaccine forms specific immunity to the causative agents of rotavirus infection, coronavirus infection, Escherichia coli, and clostridial diseases in vaccinated cows (or heifers) after double immunization. The formed antibodies are transmitted with colostrum and provide passive protection of newborn calves from rotavirus infection, coronavirus infections, Escherichia coli, and clostridial diseases up to 45 days of age. The vaccine has no therapeutic properties.
Animal species
Cattle.
Indications for use
Prevention of diarrhea in newborn calves caused by rotavirus, coronavirus infections, Escherichia coli with adhesion factor K99, and Clostridium perfringens type C.
Contraindications
The vaccine is only used in clinically healthy animals. It is not allowed to vaccinate emaciated animals and animals under stress, caused by transportation, exposure to extreme environmental conditions, helminth infestation, or other immunosuppressive states.
An intense immune response may not be present if the vaccine has not been used as indicated in the leaflet.
Precautions for use
The rules of asepsis must be followed. The vaccine in the vial should be used within 3 hours after the first withdrawal.
Special instructions during pregnancy, lactation period
The vaccine is administered to pregnant cows and heifers in the recommended doses.
Route of administration and dosage
Before vaccination, the vaccine vial should be heated to 20-25°C and shaken thoroughly. The vaccine is administered twice intramuscularly in croup in a dose of 2 ml, observing the rules of asepsis.
Primary vaccination: the vaccine is administered to heifer cows twice, approximately 3 weeks apart, so that the second dose (2.0 ml) is administered 6-3 weeks before calving.
Revaccination: a single immunization of heifers 6-3 weeks before calving is recommended annually with a dose of 2.0 ml.
The first portions of colostrum after calving are fed to newborn calves no later than 6 hours after birth. Further, colostrum from vaccinated cows, obtained in the first 6-8 milkings after calving, is recommended to be collected and stored in a refrigerator (at a temperature of 2-8°C) or frozen. The heating or thawing of colostrum is carried out at a temperature not exceeding 42°C.
Collected colostrum from vaccinated cows (6-8 milkings) is recommended to give to each calf in the volume of 2.5-3.5 L/day during the first two weeks of life.
The vaccine does not have therapeutic properties.
Withdrawal period
Zero days.
Shelf life
18 months. The vaccine should be used within 3 hours after opening the vial.
Storage and transportation conditions
In a dark place, out of reach of children at a temperature of 2 to 8°C.
Do not freeze!
Packing
Glass or plastic vials with rubber stoppers and aluminium caps, containing 5, 25, or 50 doses of the vaccine.